Les Eyzies-de-Tayac-Sireuil (often shortened to Les Eyzies) is an important UNESCO World Heritage site located in the southwest of France. Skeletons of the earliest known examples of the early modern human, the Cro-Magnon, were found in a cave outside the commune. These remains differ greatly from those of Neanderthals, a fact which has lead to important findings about the history of mankind. This and similar remarkable discoveries have led to the establishment of the National Museum of Prehistory in Les Eyzies, in addition to several important archaeological attractions in the valley of the River Vezere that are more than 40,000 years old. The prehistoric rock dwellings in the caves of Font-de-Gaume and Lascaux contain multi-colour depictions of animals and hunting culture from 17,000 years ago. Engravings in the cave of Les Combarelles reveal a higher level of mental and technical capabilities in prehistoric humans than was ever determined before. The Chateau de Commarque is a 12th century castle with a rich history relating to the region's many wars and territorial disputes, with a prehistoric cave beneath the dwelling. Les Eyzies hotels place visitors in the heart of the Europe's prehistoric wonder, offering clues to the origins of man.

other spellings: les eyzieshotels, les eyziers otel, les eyziers hotell, les eyziers hote